Research Overview
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide belonging to the melanocortin peptide family. It is investigated in laboratory systems involving melanocortin receptor pharmacology, G protein-coupled receptor signaling, receptor-subtype selectivity, central melanocortin signaling pathways, and cyclic peptide structure-function relationships.
Bremelanotide is an established pharmaceutical active substance. The PT-141 material offered by Marsden Research Labs is supplied exclusively for qualified laboratory research applications and is not offered as a pharmaceutical product or for human or veterinary use.
Chemical Information
| Compound Name | Bremelanotide |
| Common Name | PT-141 |
| Compound Type | Synthetic cyclic melanocortin receptor agonist peptide |
| Length | 7 amino-acid residues |
| Free-Base Formula | C50H68N14O10 |
| Molecular Weight | Approximately 1025.2 g/mol for bremelanotide free base. Acetate content may vary according to salt stoichiometry. |
| Acetate Form | C50H68N14O10 · xCH3COOH, where acetate stoichiometry may vary. |
| Peptide Structure | Ac-Nle-cyclo-(Asp-His-D-Phe-Arg-Trp-Lys-OH) |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on chemical form, concentration, pH, and laboratory conditions. |
| Storage | Store under appropriate laboratory conditions with protection from unnecessary heat, moisture, and light exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other analytical methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
Bremelanotide is investigated as an agonist of melanocortin receptors, a family of G protein-coupled receptors. Experimental systems use PT-141 to examine melanocortin receptor activation, receptor-subtype pharmacology, intracellular signaling, and ligand-receptor interactions.
Bremelanotide exhibits activity across multiple melanocortin receptor subtypes, providing a research model for comparing receptor selectivity and signaling within the melanocortin receptor family. Its cyclic structure also makes PT-141 useful for investigating peptide conformation, receptor binding, and structure-function relationships among synthetic melanocortin analogs.
Current Areas of Research
- Melanocortin receptor signaling
- MC1R, MC3R, and MC4R receptor pharmacology
- G protein-coupled receptor signaling
- Receptor-subtype selectivity
- Ligand-receptor interactions
- Central melanocortin signaling systems
- Cyclic peptide structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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