Research Overview
Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GHRF). It incorporates an N-terminal structural modification and is investigated in laboratory systems involving growth hormone-releasing hormone receptor (GHRHR) pharmacology, G protein-coupled receptor signaling, hypothalamic-pituitary communication, and peptide-receptor structure-function relationships.
Tesamorelin provides an experimental model for investigating how structural modification of GHRH-family peptides influences receptor binding, receptor activation, peptide stability, and comparative ligand pharmacology.
Tesamorelin is an established pharmaceutical active substance. The Tesamorelin material offered by Marsden Research Labs is supplied exclusively for qualified laboratory research applications and is not offered as a pharmaceutical product or for human or veterinary use.
Chemical Information
| Compound Name | Tesamorelin |
| Compound Type | Synthetic growth hormone-releasing hormone analog peptide |
| Length | 44 amino acids |
| Chemical Formula | C221H366N72O67S (free base) |
| Molecular Weight | Approximately 5135.9 g/mol (free-base equivalent) |
| Structural Modification | Contains a hexenoyl moiety attached to the N-terminal tyrosine residue. |
| Salt Form | Tesamorelin may be prepared in acetate form. The specific chemical form of an individual research batch should correspond to applicable analytical results. |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on chemical form, concentration, pH, and laboratory conditions. |
| Storage | Store under appropriate laboratory conditions with protection from unnecessary heat, moisture, and light exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other analytical methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
Tesamorelin is investigated as an agonist of the growth hormone-releasing hormone receptor (GHRHR), a member of the class B family of G protein-coupled receptors. Experimental systems use Tesamorelin to investigate GHRHR activation, intracellular signaling, ligand-receptor interactions, and receptor-mediated communication within hypothalamic-pituitary signaling systems.
Its modified GHRH structure also provides a model for examining how N-terminal peptide modification influences receptor pharmacology and structure-function relationships compared with endogenous GHRH and other synthetic GHRH analogs.
Current Areas of Research
- Growth hormone-releasing hormone receptor (GHRHR) signaling
- Class B G protein-coupled receptor pharmacology
- GHRH ligand-receptor interactions
- Hypothalamic-pituitary signaling
- Modified peptide pharmacology
- GHRH analog structure-function relationships
- Peptide hormone receptor biology
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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