Research Overview
MK-677, also known as Ibutamoren Mesylate, is a non-peptide small-molecule ligand investigated as an agonist of the growth hormone secretagogue receptor (GHSR-1a), commonly known as the ghrelin receptor. It is used in laboratory systems involving GHSR pharmacology, G protein-coupled receptor signaling, neuroendocrine signaling networks, receptor-ligand interactions, and small-molecule structure-function relationships.
Although commonly grouped with peptide research compounds, MK-677 is not a peptide. Ibutamoren is not FDA-approved for human use. The material offered by Marsden Research Labs is supplied exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | Ibutamoren Mesylate |
| Common Name | MK-677 / MK-0677 |
| CAS Number | 159752-10-0 |
| Compound Type | Non-peptide small-molecule GHSR agonist |
| Chemical Formula | C28H40N4O8S2 (mesylate salt) |
| Molecular Weight | Approximately 624.8 g/mol (mesylate salt) |
| Research Classification | Growth hormone secretagogue receptor (GHSR-1a) agonist research compound |
Physical Characteristics
| Appearance | White to off-white solid material; appearance may vary according to formulation and batch. |
| Solubility | Solubility characteristics depend on solvent system, formulation, and laboratory conditions. |
| Storage | Store under conditions appropriate to the individual research material and protect from unnecessary moisture and environmental exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
Ibutamoren is investigated as an agonist of the growth hormone secretagogue receptor (GHSR-1a), a G protein-coupled receptor that also serves as a receptor for ghrelin. Experimental systems use MK-677 to examine receptor activation, downstream intracellular signaling, receptor-ligand interactions, and GHSR-associated neuroendocrine signaling pathways.
As a non-peptide ligand, MK-677 also provides a research model for comparing small-molecule GHSR agonists with peptide growth hormone secretagogues and endogenous ghrelin-derived signaling systems.
Current Areas of Research
- Growth hormone secretagogue receptor (GHSR-1a) signaling
- Ghrelin receptor pharmacology
- G protein-coupled receptor signaling
- Receptor-ligand interactions
- Neuroendocrine signaling pathways
- Small-molecule GHSR agonist structure-function relationships
- Comparative secretagogue pharmacology
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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