Research Overview
TB-500 is a synthetic peptide associated with the actin-binding region of Thymosin Beta-4 (Tβ4). TB-500 is generally identified as the seven-residue Thymosin Beta-4 fragment LKKTETQ, corresponding to residues 17–23 of the endogenous Tβ4 peptide.
This region of Thymosin Beta-4 is investigated in laboratory systems involving actin-associated peptide interactions, cytoskeletal dynamics, cellular migration pathways, and short-peptide structure-function relationships.
TB-500 is not an FDA-approved drug substance for human use. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | TB-500 |
| Research Identity | Thymosin Beta-4 fragment (17–23) |
| Compound Type | Synthetic Thymosin Beta-4-derived peptide fragment |
| Length | 7 amino acids |
| Peptide Sequence | Leu-Lys-Lys-Thr-Glu-Thr-Gln (LKKTETQ) |
| Common Modified Form | N-terminally acetylated Ac-LKKTETQ |
| Molecular Characteristics | Dependent on the specific chemical form of the research material and should be confirmed by applicable analytical results. |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on chemical form, concentration, pH, and laboratory conditions. |
| Storage | Store under appropriate laboratory conditions with protection from unnecessary heat, moisture, and light exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods capable of distinguishing the applicable peptide form. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other analytical methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
The LKKTETQ sequence corresponds to a central actin-associated region of Thymosin Beta-4. Experimental research involving this sequence has examined its relationship to actin-associated cellular processes, cytoskeletal organization, and cellular migration pathways.
TB-500 therefore provides a laboratory model for investigating short peptide interactions associated with Thymosin Beta-4 biology, actin-related signaling systems, cytoskeletal regulation, and structure-function relationships between full-length Tβ4 and its derived peptide fragments.
The biological properties of TB-500 should not automatically be assumed to be identical to those of full-length Thymosin Beta-4, and the specific activity of individual TB-500 preparations depends on peptide identity, chemical modification, and experimental conditions.
Current Areas of Research
- Thymosin Beta-4 fragment biology
- Actin-associated peptide interactions
- Cytoskeletal dynamics
- Cellular migration pathways
- Peptide-actin structure-function relationships
- Short regulatory peptide biology
- Comparative Tβ4 fragment research
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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