Description
Research Overview
Melanotan I, also known as Afamelanotide, is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH). It is widely studied in laboratory research for its interactions with melanocortin receptors, particularly the melanocortin-1 receptor (MC1R), as well as pigmentation biology, photoprotection, inflammatory signaling, and neuroendocrine physiology.
Melanotan I is an investigational research peptide when supplied for laboratory use and is provided by Marsden Research Labs exclusively for qualified laboratory research applications. It is not offered for human or veterinary use.
Chemical Information
| Compound Name | Melanotan I |
| Common Name | Afamelanotide |
| Compound Type | Synthetic α-melanocyte-stimulating hormone (α-MSH) analog |
| Length | 13 amino acids |
| Molecular Weight | Approximately 1.6 kDa |
| Structure | Modified α-MSH analog containing substitutions that increase biological stability and receptor affinity. |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term stability. |
| Stability | Stability depends on laboratory storage conditions, handling, and repeated freeze-thaw exposure. |
Analytical Verification
Every batch offered by Marsden Research Labs is supported by batch-specific analytical verification whenever documentation is available. Analytical testing is performed to verify identity, assess purity, and provide supporting laboratory documentation for individual research batches.
| Identity Verification | Confirmed using Liquid Chromatography–Mass Spectrometry (LC-MS) when available. |
| Purity Analysis | Determined using High-Performance Liquid Chromatography (HPLC). |
| Batch Documentation | Each verified research batch is assigned a unique batch identifier for traceability. |
| Certificate of Analysis (COA) | Available for verified batches and includes analytical testing results when provided. |
| Laboratory Report | Additional laboratory documentation is provided for applicable batches when available. |
Batch-Specific Information
The batch number, purity value, testing date, Certificate of Analysis (COA), and laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Mechanism of Action
Melanotan I functions primarily as an agonist of the melanocortin-1 receptor (MC1R), activating intracellular signaling pathways involved in melanogenesis and pigment production. Laboratory studies have also investigated its interactions with additional melanocortin receptors, inflammatory signaling pathways, oxidative stress responses, and neuroendocrine regulation. Due to its enhanced stability compared with endogenous α-MSH, it serves as a valuable tool for studying melanocortin receptor biology.
Because of its biological activity, Melanotan I is frequently investigated in pigmentation biology, melanocortin receptor pharmacology, photobiology, inflammatory signaling, and neuroendocrine physiology.
Current Areas of Research
- Melanocortin-1 receptor (MC1R) signaling
- Melanogenesis and pigmentation biology
- Photoprotection research
- Inflammatory signaling pathways
- Melanocortin receptor pharmacology
- Neuroendocrine physiology
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored according to accepted laboratory practices to preserve compound integrity. Stability may be affected by storage conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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