Research Overview
Melanotan I, also known as Afamelanotide, is a synthetic 13-amino-acid analog of α-melanocyte-stimulating hormone (α-MSH). It is investigated in laboratory systems involving melanocortin receptor pharmacology, particularly melanocortin-1 receptor (MC1R) signaling, G protein-coupled receptor pathways, cyclic AMP signaling, melanocyte biology, and peptide-receptor structure-function relationships.
Afamelanotide has received regulatory approval for specified pharmaceutical use. The material offered by Marsden Research Labs is supplied exclusively as a laboratory research material and is not offered as a pharmaceutical product or for human or veterinary use.
Chemical Information
| Compound Name | Melanotan I |
| Common Name | Afamelanotide |
| Compound Type | Synthetic α-melanocyte-stimulating hormone (α-MSH) analog |
| Length | 13 amino acids |
| Chemical Formula | C78H111N21O19 (free base) |
| Molecular Weight | Approximately 1646.85 g/mol for the free base; salt forms should be referenced from applicable batch documentation. |
| Amino Acid Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term laboratory storage. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
Afamelanotide is investigated as a melanocortin receptor agonist with predominant interaction at the melanocortin-1 receptor (MC1R). Experimental systems use the peptide to examine MC1R activation, G protein-coupled receptor signaling, cyclic AMP-associated intracellular pathways, and melanocyte signaling biology.
The structural modifications distinguishing Afamelanotide from endogenous α-MSH also make it useful for investigating melanocortin receptor binding, peptide stability, receptor-ligand interactions, and structure-function relationships within the melanocortin signaling system.
Current Areas of Research
- Melanocortin-1 receptor (MC1R) signaling
- Melanocortin receptor pharmacology
- G protein-coupled receptor signaling
- Cyclic AMP-associated pathways
- Melanocyte cellular signaling
- α-MSH analog structure-function relationships
- Peptide-receptor binding interactions
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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