Research Overview
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside), also known as acadesine or AICA riboside, is a synthetic research compound widely used in experimental systems involving AMP-activated protein kinase (AMPK) signaling, cellular energy sensing, metabolic pathway regulation, and mitochondrial biology.
AICAR is an investigational research compound. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | 5-Aminoimidazole-4-carboxamide ribonucleoside |
| Common Names | AICAR, AICA Riboside, Acadesine |
| CAS Number | 2627-69-2 |
| Compound Type | Synthetic ribonucleoside research compound |
| Chemical Formula | C9H14N4O5 |
| Molecular Weight | Approximately 258.23 g/mol |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term laboratory storage. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) analysis. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
AICAR is taken up by cells in experimental systems and phosphorylated intracellularly to form ZMP (AICA ribotide), an AMP-related metabolite. ZMP is widely studied for its interaction with AMP-sensitive cellular pathways, including AMP-activated protein kinase (AMPK) signaling.
AICAR is therefore commonly used as a laboratory research tool for investigating cellular energy sensing, kinase signaling, mitochondrial biology, metabolic pathway regulation, and cellular stress-response mechanisms.
Current Areas of Research
- AMP-activated protein kinase (AMPK) signaling
- Cellular energy-sensing pathways
- Mitochondrial biology and bioenergetics
- Nucleotide and purine metabolism
- Metabolic signaling pathways
- Cellular stress-response signaling
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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