Description
Research Overview
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic nucleoside analog widely studied in laboratory research for its ability to activate adenosine monophosphate-activated protein kinase (AMPK). It is commonly investigated for its role in cellular energy regulation, metabolic signaling, mitochondrial function, and glucose metabolism.
AICAR is an investigational research compound and is not approved for therapeutic use in humans. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | 5-Aminoimidazole-4-carboxamide ribonucleotide |
| Common Name | AICAR |
| Compound Type | Synthetic nucleoside analog |
| Chemical Formula | C9H14N4O8P |
| Molecular Weight | Approximately 338.2 g/mol |
| Chemical Structure | Ribonucleotide analog structurally related to adenosine monophosphate (AMP). |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term stability. |
| Stability | Stability depends on laboratory storage conditions, handling, and repeated freeze-thaw exposure. |
Analytical Verification
Every batch offered by Marsden Research Labs is supported by batch-specific analytical verification whenever documentation is available. Analytical testing is performed to verify identity, assess purity, and provide supporting laboratory documentation for individual research batches.
| Identity Verification | Confirmed using Liquid Chromatography–Mass Spectrometry (LC-MS) when available. |
| Purity Analysis | Determined using High-Performance Liquid Chromatography (HPLC). |
| Batch Documentation | Each verified research batch is assigned a unique batch identifier for traceability. |
| Certificate of Analysis (COA) | Available for verified batches and includes analytical testing results when provided. |
| Laboratory Report | Additional laboratory documentation is provided for applicable batches when available. |
Batch-Specific Information
The batch number, purity value, testing date, Certificate of Analysis (COA), and laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Mechanism of Action
AICAR is transported into cells where it is converted to ZMP (AICA ribotide), an AMP analog that activates adenosine monophosphate-activated protein kinase (AMPK). Activation of AMPK influences numerous cellular pathways involved in energy homeostasis, glucose uptake, lipid metabolism, mitochondrial biogenesis, and cellular stress responses.
Because of its biological activity, AICAR is frequently investigated in metabolic research, exercise physiology, mitochondrial biology, and cellular energy regulation studies.
Current Areas of Research
- AMP-activated protein kinase (AMPK) signaling
- Cellular energy metabolism
- Mitochondrial function and biogenesis
- Glucose metabolism research
- Lipid metabolism pathways
- Exercise physiology and metabolic adaptation
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored according to accepted laboratory practices to preserve compound integrity. Stability may be affected by storage conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
Reviews
There are no reviews yet.