Research Overview
Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide family. Synthetic VIP, also known as Aviptadil, is investigated in laboratory systems involving vasoactive intestinal peptide receptor pharmacology, class B G protein-coupled receptor signaling, cyclic AMP-associated pathways, neuropeptide signaling, and peptide-receptor structure-function relationships.
VIP provides an experimental model for investigating signaling through the VPAC1 and VPAC2 receptor systems and for comparing ligand activity within the broader secretin-family peptide receptor network.
The VIP material offered by Marsden Research Labs is supplied exclusively for qualified laboratory research applications and is not offered as a pharmaceutical product or for human or veterinary use.
Chemical Information
| Compound Name | Vasoactive Intestinal Peptide |
| Common Name | VIP |
| Synthetic Name | Aviptadil |
| Compound Type | Synthetic form of an endogenous neuropeptide |
| Peptide Family | Secretin/glucagon peptide family |
| Length | 28 amino acids |
| Chemical Formula | C147H238N44O42S |
| Molecular Weight | Approximately 3325.8 g/mol |
| Amino Acid Sequence | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on concentration, pH, formulation, and laboratory conditions. |
| Storage | Store under appropriate laboratory conditions with protection from unnecessary heat, moisture, and light exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other analytical methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
VIP is investigated as an endogenous ligand of the vasoactive intestinal peptide receptors VPAC1 and VPAC2. These receptors belong to the class B family of G protein-coupled receptors and provide experimental systems for examining ligand binding, receptor activation, G protein-mediated signaling, and cyclic AMP-associated intracellular pathways.
Laboratory systems use VIP to compare signaling characteristics between VPAC1 and VPAC2, investigate receptor-selectivity relationships, and examine interactions among VIP, related peptide ligands, and secretin-family receptor systems.
The defined 28-amino-acid structure of VIP also provides a model for investigating peptide conformation, receptor recognition, sequence-function relationships, and structural determinants of class B GPCR ligand activity.
Current Areas of Research
- VPAC1 receptor signaling
- VPAC2 receptor signaling
- Class B G protein-coupled receptor pharmacology
- cAMP-associated intracellular signaling
- Ligand-receptor interactions
- Receptor selectivity and comparative activity
- Secretin-family peptide biology
- Peptide-receptor structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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