Description
Research Overview
FOXO4-DRI (Forkhead Box O4 D-Retro-Inverso) is a synthetic D-retro-inverso peptide engineered to disrupt the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53. It is widely studied in laboratory research as a selective senolytic tool for investigating cellular senescence, apoptosis signaling, aging biology, and tissue homeostasis.
FOXO4-DRI is an investigational research peptide and has not been approved for therapeutic use in humans. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | FOXO4-DRI |
| Common Name | Forkhead Box O4 D-Retro-Inverso Peptide |
| Compound Type | Synthetic D-retro-inverso peptide |
| Length | D-retro-inverso peptide engineered from the FOXO4 p53-binding domain |
| Molecular Weight | Varies according to synthesis and formulation |
| Peptide Structure | D-retro-inverso analog designed to improve proteolytic stability while preserving the three-dimensional binding characteristics of the native FOXO4 interaction domain. |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term stability. |
| Stability | Stability depends on laboratory storage conditions, handling, and repeated freeze-thaw exposure. |
Analytical Verification
Every batch offered by Marsden Research Labs is supported by batch-specific analytical verification whenever documentation is available. Analytical testing is performed to verify identity, assess purity, and provide supporting laboratory documentation for individual research batches.
| Identity Verification | Confirmed using Liquid Chromatography–Mass Spectrometry (LC-MS) when available. |
| Purity Analysis | Determined using High-Performance Liquid Chromatography (HPLC). |
| Batch Documentation | Each verified research batch is assigned a unique batch identifier for traceability. |
| Certificate of Analysis (COA) | Available for verified batches and includes analytical testing results when provided. |
| Laboratory Report | Additional laboratory documentation is provided for applicable batches when available. |
Batch-Specific Information
The batch number, purity value, testing date, Certificate of Analysis (COA), and laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Mechanism of Action
FOXO4-DRI is designed to selectively disrupt the interaction between FOXO4 and p53 within senescent cells. In laboratory studies, this disruption permits p53 translocation and activation of apoptotic signaling pathways, resulting in the selective elimination of senescent cells while largely sparing proliferating healthy cells. The D-retro-inverso design increases resistance to enzymatic degradation, making the peptide more suitable for experimental investigations.
Because of its biological activity, FOXO4-DRI is frequently investigated in senescence biology, aging research, apoptosis signaling, tissue regeneration, and cellular homeostasis.
Current Areas of Research
- Cellular senescence biology
- FOXO4-p53 signaling pathways
- Apoptosis regulation
- Healthy aging research
- Tissue homeostasis and regeneration
- Senolytic peptide development
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored according to accepted laboratory practices to preserve compound integrity. Stability may be affected by storage conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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