Research Overview
FOXO4-DRI (Forkhead Box O4 D-Retro-Inverso) is a synthetic D-retro-inverso peptide investigated as a molecular research tool for studying the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53. It is used in experimental systems involving cellular senescence, protein-protein interactions, p53-associated signaling, apoptosis pathways, and cellular homeostasis.
FOXO4-DRI is an investigational research peptide and has not been approved for therapeutic use in humans. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | FOXO4-DRI |
| Common Name | Forkhead Box O4 D-Retro-Inverso Peptide |
| Compound Type | Synthetic D-retro-inverso peptide |
| Structural Origin | D-retro-inverso peptide derived from a FOXO4 interaction-domain sequence. |
| Molecular Characteristics | Batch-specific molecular characteristics should be referenced from applicable synthesis and analytical documentation. |
| Peptide Structure | D-retro-inverso configuration designed to preserve relevant side-chain topology while increasing resistance to proteolytic degradation. |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Solubility characteristics depend on peptide form, formulation, and laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term laboratory storage. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) analysis. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
FOXO4-DRI is investigated as a peptide designed to perturb the protein-protein interaction between FOXO4 and p53. Experimental senescent-cell models have used FOXO4-DRI to examine how disruption of this interaction affects p53 localization, p53-dependent apoptotic signaling, and cellular viability.
The D-retro-inverso configuration is also of interest in peptide research because it permits investigation of structure-function relationships, proteolytic stability, intracellular peptide interactions, and protein-binding mechanisms.
Current Areas of Research
- FOXO4-p53 protein interactions
- Cellular senescence biology
- p53-associated signaling pathways
- Apoptosis signaling
- Protein-protein interaction research
- D-retro-inverso peptide structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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