Description
Research Overview
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic analog of human insulin-like growth factor-1 (IGF-1) engineered to possess an extended biological half-life and reduced affinity for insulin-like growth factor binding proteins (IGFBPs). It is widely studied in laboratory research for its interactions with the insulin-like growth factor-1 receptor (IGF-1R), cellular proliferation, protein synthesis, metabolic signaling, and intracellular growth pathways.
IGF-1 LR3 is an investigational research peptide and has not been approved for therapeutic use in humans. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | Long R3 Insulin-Like Growth Factor-1 |
| Common Name | IGF-1 LR3 |
| Compound Type | Synthetic insulin-like growth factor analog |
| Length | 83 amino acids |
| Molecular Weight | Approximately 9.2 kDa |
| Structure | Modified IGF-1 analog containing a 13-amino acid N-terminal extension and an Arg substitution at position 3 to reduce IGFBP binding and extend biological activity. |
Physical Characteristics
| Appearance | White to off-white lyophilized powder. |
| Solubility | Water soluble under laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term stability. |
| Stability | Stability depends on laboratory storage conditions, handling, and repeated freeze-thaw exposure. |
Analytical Verification
Every batch offered by Marsden Research Labs is supported by batch-specific analytical verification whenever documentation is available. Analytical testing is performed to verify identity, assess purity, and provide supporting laboratory documentation for individual research batches.
| Identity Verification | Confirmed using Liquid Chromatography–Mass Spectrometry (LC-MS) when available. |
| Purity Analysis | Determined using High-Performance Liquid Chromatography (HPLC). |
| Batch Documentation | Each verified research batch is assigned a unique batch identifier for traceability. |
| Certificate of Analysis (COA) | Available for verified batches and includes analytical testing results when provided. |
| Laboratory Report | Additional laboratory documentation is provided for applicable batches when available. |
Batch-Specific Information
The batch number, purity value, testing date, Certificate of Analysis (COA), and laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Mechanism of Action
IGF-1 LR3 functions as an agonist of the insulin-like growth factor-1 receptor (IGF-1R), activating intracellular signaling pathways including PI3K/Akt and MAPK/ERK that regulate cellular proliferation, protein synthesis, metabolism, differentiation, and survival. Structural modifications reduce binding to insulin-like growth factor binding proteins (IGFBPs), resulting in prolonged receptor availability and extended biological activity during laboratory investigations.
Because of its biological activity, IGF-1 LR3 is frequently investigated in growth factor biology, cellular signaling, protein synthesis, metabolic regulation, and endocrine physiology.
Current Areas of Research
- Insulin-like growth factor-1 receptor (IGF-1R) signaling
- Cellular proliferation and differentiation
- Protein synthesis pathways
- PI3K/Akt and MAPK signaling
- Growth factor biology
- Metabolic pathway investigation
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored according to accepted laboratory practices to preserve compound integrity. Stability may be affected by storage conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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