Research Overview
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-I) is a modified analog of human insulin-like growth factor-I (IGF-I). It contains an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, producing an 83-amino-acid polypeptide with substantially reduced affinity for insulin-like growth factor-binding proteins (IGFBPs).
IGF-1 LR3 is investigated in laboratory systems involving insulin-like growth factor-I receptor (IGF-1R) signaling, growth-factor receptor pharmacology, IGFBP interactions, intracellular kinase signaling, and cellular regulatory pathways.
IGF-1 LR3 is an investigational research material and has not been approved for therapeutic use in humans. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | Long R3 Insulin-Like Growth Factor-I |
| Common Name | IGF-1 LR3 / Long R3 IGF-I |
| Compound Type | Modified insulin-like growth factor-I polypeptide analog |
| Length | 83 amino acids |
| Molecular Weight | Approximately 9.1 kDa; exact molecular characteristics should be referenced from applicable batch documentation. |
| Structural Characteristics | IGF-I analog containing an Arg substitution at position 3 and a 13-amino-acid N-terminal extension associated with reduced IGFBP binding. |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on formulation and laboratory conditions. |
| Storage | Store frozen at -20°C or below for long-term laboratory storage. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
IGF-1 LR3 is investigated as a ligand of the insulin-like growth factor-I receptor (IGF-1R). Experimental systems use the analog to examine receptor activation, receptor-associated kinase signaling, and downstream intracellular pathways including PI3K/Akt and MAPK/ERK signaling.
Its modified structure and reduced interaction with insulin-like growth factor-binding proteins also make IGF-1 LR3 useful for investigating IGF-IGFBP interactions, growth-factor bioavailability in experimental systems, receptor-binding relationships, and structure-function differences between native and modified IGF-I molecules.
Current Areas of Research
- Insulin-like growth factor-I receptor (IGF-1R) signaling
- IGF-binding protein (IGFBP) interactions
- PI3K/Akt signaling pathways
- MAPK/ERK signaling pathways
- Growth-factor receptor pharmacology
- IGF-I analog structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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