Research Overview
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) reported to be encoded within an open reading frame associated with the mitochondrial 12S rRNA region. Synthetic MOTS-c is investigated in laboratory systems involving mitochondrial signaling, cellular stress-response pathways, AMPK-associated signaling, mitochondrial-nuclear communication, and regulation of cellular gene-expression networks.
Experimental studies have also examined MOTS-c as a model for understanding communication between mitochondrial genetic information and nuclear cellular responses under conditions of metabolic and cellular stress.
MOTS-c is an investigational research peptide and is not FDA-approved for human use. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | MOTS-c |
| Compound Type | Mitochondrial-derived research peptide |
| Length | 16 amino acids |
| Chemical Formula | C101H152N28O22S2 (free base) |
| Molecular Weight | Approximately 2174.6 g/mol for MOTS-c free base; salt forms should be referenced from applicable batch documentation. |
| Amino Acid Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Reported to be soluble in water under laboratory conditions; solubility may vary according to formulation and experimental conditions. |
| Storage | Store at -20°C or below for long-term laboratory storage, desiccated and protected from light. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
The molecular mechanisms associated with MOTS-c remain under investigation. Experimental studies have examined MOTS-c in relation to AMPK-associated signaling, folate and purine metabolic pathways, cellular stress responses, and mitochondrial-nuclear communication.
Under experimentally induced cellular stress conditions, MOTS-c has been observed to translocate to the nucleus in an AMPK-dependent manner and interact with nuclear regulatory systems associated with stress-responsive gene expression. These findings provide experimental models for investigating communication between mitochondrial-derived peptides and nuclear signaling networks.
Current Areas of Research
- Mitochondrial-derived peptide biology
- AMPK-associated signaling
- Mitochondrial-nuclear communication
- Cellular stress-response signaling
- Stress-responsive gene expression
- Folate and purine metabolic pathways
- Mitochondrial peptide structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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