Research Overview
Survodutide, also known as BI 456906, is a synthetic modified peptide investigated as a dual agonist of the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R). It is used in laboratory systems involving dual-receptor pharmacology, class B G protein-coupled receptor signaling, intracellular second-messenger pathways, receptor selectivity, and peptide structure-function relationships.
Survodutide incorporates structural modification, including peptide acylation, that distinguishes it from endogenous glucagon-family peptide ligands and provides an experimental model for investigating modified dual-receptor agonists.
Survodutide remains an investigational compound and is not approved for human use. This material is supplied by Marsden Research Labs exclusively for qualified laboratory research applications and is not offered for human or veterinary use.
Chemical Information
| Compound Name | Survodutide |
| Research Code | BI 456906 |
| Compound Type | Synthetic modified dual-receptor agonist peptide |
| Receptor Profile | Glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R) agonist |
| Chemical Formula | C192H289N47O61 |
| Molecular Weight | Approximately 4232 g/mol |
| Structural Characteristics | Acylated peptide incorporating a C18 fatty-acid modification. |
Physical Characteristics
| Appearance | White to off-white lyophilized material. |
| Solubility | Solubility characteristics depend on concentration, pH, formulation, and laboratory conditions. |
| Storage | Store under appropriate laboratory conditions with protection from unnecessary heat, moisture, and light exposure. |
| Stability | Stability depends on the characteristics of the research material and may be affected by storage temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and laboratory handling. |
Analytical Verification
Every batch made available for purchase by Marsden Research Labs is supported by current, batch-specific third-party laboratory documentation. Products are not made available for purchase until applicable testing and Certificate of Analysis (COA) documentation are complete. Additional independent laboratory reports may be published for a batch when available.
| Identity Verification | May include Liquid Chromatography–Mass Spectrometry (LC-MS) or comparable analytical methods. |
| Purity Analysis | May include High-Performance Liquid Chromatography (HPLC) or other analytical methods appropriate to the individual sample. |
| Quantitative Analysis | May include quantitative assessment appropriate to the individual batch and analytical method. |
| Batch Traceability | Research batches are assigned unique batch identifiers corresponding to their applicable analytical results and documentation. |
| Certificate of Analysis (COA) | Required for every batch made available for purchase and reflects the analytical results associated with that batch. |
| Laboratory Report | Additional independent laboratory reports may be published for a batch when available. |
Batch-Specific Information
The batch number, analytical results, testing date, Certificate of Analysis (COA), and any additional independent laboratory report displayed near the top of this page correspond to the selected research sample and update automatically when a different batch or package size is selected.
Investigated Molecular Mechanisms
Survodutide is investigated as an agonist of the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R). Both receptors belong to the class B family of G protein-coupled receptors and provide experimental systems for examining receptor activation, intracellular second-messenger signaling, and ligand-receptor interactions.
The dual-receptor profile of Survodutide allows researchers to investigate relative activity at GCGR and GLP-1R, receptor-selectivity relationships, coordinated signaling across two related receptor systems, and differences between dual agonists and selective receptor ligands.
Its modified and acylated peptide structure also provides an experimental model for investigating how structural modification influences peptide-receptor pharmacology and ligand structure-function relationships.
Current Areas of Research
- Glucagon receptor (GCGR) signaling
- GLP-1 receptor (GLP-1R) signaling
- Dual-receptor agonist pharmacology
- Class B G protein-coupled receptor signaling
- Intracellular second-messenger pathways
- Receptor selectivity and comparative potency
- Acylated peptide pharmacology
- Peptide-receptor structure-function relationships
Marsden Research Labs makes no representation regarding clinical outcomes or therapeutic applications.
Laboratory Handling
This material should be handled only by qualified laboratory personnel using appropriate research procedures.
Research samples should be stored and handled according to accepted laboratory practices appropriate to the research material. Material integrity may be affected by temperature, moisture, light exposure, solution conditions, repeated freeze-thaw cycles, and handling methods.
Research Use Notice
This product is supplied exclusively for laboratory research purposes.
It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, food use, cosmetic use, or consumption of any kind. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the acquisition and use of research materials.
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